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Major Depressive Disorder News

intranasal spray bottles
Research Summary
11/02/2026
Brionna Mendoza
A single administration of mebufotenin benzoate nasal spray produced rapid, sustained reductions in depressive symptoms among adults with TRD, according to a phase 2b trial published in JAMA.
A single administration of mebufotenin benzoate nasal spray produced rapid, sustained reductions in depressive symptoms among adults with TRD, according to a phase 2b trial published in JAMA.
A single administration of...
11/02/2026
Psych Congress Network
3D illustration of a brain in blue and white against a black background
Research Summary
10/21/2026
Brionna Mendoza
Home transcranial direct current stimulation paired with cognitive training delivered through a video game was feasible but offered no superior antidepressant benefit in a randomized clinical trial published in JAMA Network Open.
Home transcranial direct current stimulation paired with cognitive training delivered through a video game was feasible but offered no superior antidepressant benefit in a randomized clinical trial published in JAMA Network Open.
Home transcranial direct current...
10/21/2026
Psych Congress Network
Head in profile with brain visible and target over brain
Research Summary
10/08/2026
Brionna Mendoza
A connectivity-guided approach to accelerated iTBS produced greater short-term reductions in depression severity than conventional scalp-based targeting.
A connectivity-guided approach to accelerated iTBS produced greater short-term reductions in depression severity than conventional scalp-based targeting.
A connectivity-guided approach...
10/08/2026
Psych Congress Network
A selection of ultraprocessed foods, including donuts, hamburgers, pizza, and fries.
News
09/25/2026
Brionna Mendoza
Reducing ultraprocessed food consumption was feasible and acceptable among adults with major depressive disorder (MDD) and was associated with lower depression and anxiety scores.
Reducing ultraprocessed food consumption was feasible and acceptable among adults with major depressive disorder (MDD) and was associated with lower depression and anxiety scores.
Reducing ultraprocessed food...
09/25/2026
Psych Congress Network
older woman with depression
Research Summary
09/23/2026
Maria Mantas
Vortioxetine was consistently associated with reduced depressive symptoms in older adults with MDD, while its effects on cognition were less consistent, according to a systematic review.
Vortioxetine was consistently associated with reduced depressive symptoms in older adults with MDD, while its effects on cognition were less consistent, according to a systematic review.
Vortioxetine was consistently...
09/23/2026
Psych Congress Network
fda building sign
News
09/09/2026
Brionna Mendoza
The US FDA has granted Breakthrough Therapy designation to DT120, an orally disintegrating lysergide tablet, for the treatment of MDD.
The US FDA has granted Breakthrough Therapy designation to DT120, an orally disintegrating lysergide tablet, for the treatment of MDD.
The US FDA has granted...
09/09/2026
Psych Congress Network
a woman holds her head in her hands
Research Summary
09/01/2026
Maria Mantas
Negative expectations about the future were associated with differences in brain structure and a longer course of depressive illness among patients with MDD.
Negative expectations about the future were associated with differences in brain structure and a longer course of depressive illness among patients with MDD.
Negative expectations about the...
09/01/2026
Psych Congress Network
A pregnant woman attends her doctor's appointment
News
08/18/2026
Brionna Mendoza
Treating MDD during pregnancy should be prioritized as part of maternal and fetal health care, argued the authors of a Special Communication published in JAMA Psychiatry.
Treating MDD during pregnancy should be prioritized as part of maternal and fetal health care, argued the authors of a Special Communication published in JAMA Psychiatry.
Treating MDD during pregnancy...
08/18/2026
Psych Congress Network
a worried woman looks out a window
Research Summary
08/14/2026
Maria Mantas
In a preregistered study of 106 adults, individuals with major depressive disorder (MDD) reported more mind-wandering than healthy controls during a continuous performance task.
In a preregistered study of 106 adults, individuals with major depressive disorder (MDD) reported more mind-wandering than healthy controls during a continuous performance task.
In a preregistered study of 106...
08/14/2026
Psych Congress Network
a man smokes a cigarette
Research Summary
08/13/2026
Maria Mantas
Baseline alcohol, nicotine, and cannabis use was largely not associated with antidepressant response to rTMS among patients with MDD, according to study findings.
Baseline alcohol, nicotine, and cannabis use was largely not associated with antidepressant response to rTMS among patients with MDD, according to study findings.
Baseline alcohol, nicotine, and...
08/13/2026
Psych Congress Network